Psychosis is primarily treated with antipsychotic medications, which help reduce or eliminate symptoms like hallucinations, delusions, and disorganized thinking. These drugs work by balancing brain chemicals—especially dopamine—that become overactive during psychotic episodes.

Two Main Classes of Antipsychotics

1. Second-Generation (Atypical) Antipsychotics – First-Line Treatment

These are most commonly prescribed because they effectively treat psychosis while causing fewer movement-related side effects. Common options include:

• Aripiprazole (Abilify)
• Risperidone (Risperdal)
• Quetiapine (Seroquel)
• Olanzapine (Zyprexa)
• Paliperidone (Invega)

They also help with mood and anxiety symptoms often seen alongside psychosis.

2. First-Generation (Typical) Antipsychotics – Less Common Today

Older medications like haloperidol (Haldol) or chlorpromazine are still used in emergencies or specific cases but carry a higher risk of side effects like muscle stiffness, tremors, or restlessness (called extrapyramidal symptoms).

The Gold Standard for Treatment-Resistant Cases

When two or more antipsychotics fail, clozapine (Clozaril) is prescribed. It’s the most effective medication for severe or persistent psychosis—especially in schizophrenia—and is the only one proven to reduce suicide risk. Because it can rarely affect white blood cell levels, it requires regular blood monitoring.

Long-Acting Injectables (LAIs)

For people who struggle with daily pills, monthly or biweekly injections (like risperidone LAI or paliperidone palmitate) ensure consistent medication levels and reduce relapse risk.

Important Considerations

• Medication works best when combined with therapy, family support, and stable routines.
• Finding the right drug and dose takes time—side effects (like weight gain, drowsiness, or restlessness) must be managed carefully.
• Never stop antipsychotics suddenly—this can trigger a relapse. Always work with a psychiatrist.

Antipsychotic medications don’t “cure” psychosis, but they create the stability needed for healing. With the right treatment, many people regain clarity, reconnect with life, and prevent future episodes. The goal isn’t just symptom control—it’s a return to self.