Among commonly used substances, methamphetamine is associated with the highest rate of drug-induced psychosis. Studies show that up to 40% of people who use methamphetamine regularly experience symptoms like hallucinations, delusions, or paranoia—sometimes even after stopping use.

Why Methamphetamine Tops the List

Methamphetamine drastically alters brain chemistry by flooding it with dopamine, a neurotransmitter tied to reward and perception. With repeated use, this can overstimulate the brain and trigger a psychotic state that closely resembles schizophrenia. Symptoms may include:

• Hearing voices (auditory hallucinations)
• Believing others are plotting against you (paranoid delusions)
• Extreme agitation or aggression
• Disorganized thinking

While other drugs can also cause psychosis—such as cocaine, cannabis (especially high-THC strains), LSD, or even high-dose prescription stimulants—methamphetamine carries the highest risk, both in likelihood and severity. In some cases, psychosis can persist for weeks, months, or even become chronic, particularly with long-term or heavy use.

Important Note:
Drug-induced psychosis is a medical emergency. It can be dangerous to the person and others. Early intervention—stopping drug use and seeking psychiatric care—greatly improves outcomes. In many cases, symptoms fade with abstinence and treatment, but delayed help increases the risk of lasting mental health issues.

If you or someone you know is experiencing psychosis after drug use, seek professional medical help immediately.