Bipolar disorder is sensitive to internal and external changes. Certain factors can worsen mood episodes or trigger relapse—even in people on treatment.

Disrupted Sleep Patterns
Irregular sleep is one of the strongest triggers. Staying up late, jet lag, or shift work can ignite mania. Poor sleep also deepens depression. Consistent rest is essential for stability.

Stressful Life Events
Major changes—like job loss, breakups, or financial trouble—can destabilize mood. Even positive events, such as weddings or promotions, may trigger mania if they cause overexcitement.

Substance Use
Alcohol, cannabis, stimulants, and even excessive caffeine can interfere with medication and brain chemistry. Substance use often leads to more frequent and severe episodes.

Medication Non-Adherence
Skipping or stopping mood stabilizers—especially when feeling “fine”—is a leading cause of relapse. Mania can return within days or weeks without treatment.

Hormonal Shifts
Puberty, pregnancy, postpartum periods, and thyroid imbalances may worsen symptoms. Women with bipolar often experience mood changes around their menstrual cycle.

Overstimulation
Loud environments, excessive screen time, or chaotic schedules can heighten anxiety and agitation—particularly during mixed or manic states.

Social Isolation
Withdrawing from support networks removes emotional grounding. Loneliness can fuel depression, while lack of feedback may let manic thinking go unchecked.

Certain Medications
Antidepressants (without a mood stabilizer), steroids, or decongestants may trigger mania. Always consult a psychiatrist before starting any new drug.

Understanding what aggravates bipolar disorder helps you build a protective routine. Track your mood, stick to treatment, and reduce known triggers. Small daily choices—like bedtime consistency or avoiding drugs—make a big difference in long-term stability. Work closely with your care team to personalize your prevention plan.