There’s no single “best” antidepressant for everyone—because depression affects people differently. However, SSRIs (Selective Serotonin Reuptake Inhibitors) are often the first-choice medication due to their effectiveness and relatively mild side effects.
Common First-Line Antidepressants
- Sertraline (Zoloft) and escitalopram (Lexapro) are widely prescribed. They help boost serotonin, a brain chemical linked to mood, sleep, and appetite.
- Fluoxetine (Prozac) and citalopram (Celexa) are also commonly used, especially for long-term management.
These medications typically take 4 to 6 weeks to show full effects. They’re generally well-tolerated, with side effects like nausea, headache, or mild insomnia often fading over time.
Other Options When SSRIs Don’t Work
If SSRIs aren’t effective, doctors may try:
- SNRIs (e.g., venlafaxine, duloxetine), which affect both serotonin and norepinephrine
- Atypical antidepressants like bupropion (Wellbutrin), which may help with fatigue or low motivation—and doesn’t cause sexual side effects
- Mirtazapine, which can improve sleep and appetite
- For treatment-resistant depression, options like augmentation with lithium, atypical antipsychotics (e.g., aripiprazole), or newer therapies like ketamine or esketamine (Spravato) may be considered
Medication Is Just One Part of Treatment
The best approach often combines medication with psychotherapy (like CBT), lifestyle changes (exercise, sleep, nutrition), and social support. What works best depends on your symptoms, medical history, genetics, and personal preferences.
Always work with a healthcare provider to choose and adjust antidepressants—never stop or switch medication without medical guidance.
The “best” medicine for depression is the one that works safely and sustainably for you—with support from a trusted care team.