While vitamins alone can’t cure depression or anxiety, certain nutrients support brain health and may help ease symptoms—especially when deficiencies are present. Always talk to a doctor before starting supplements, as they work best alongside therapy, medication, and lifestyle changes.

Key Vitamins for Mood Support

Vitamin D is strongly linked to mood regulation. Low levels are common in people with depression. Sunlight exposure and supplements (if deficient) may improve energy and emotional well-being.

B vitamins—especially B6, B9 (folate), and B12—help produce serotonin and dopamine, brain chemicals that affect mood. Low folate, for example, is tied to poorer response to antidepressants. Foods like leafy greens, eggs, and fortified grains are good sources.

Vitamin B12 deficiency can mimic depression or cause fatigue and brain fog—common in older adults or those on plant-based diets.

Magnesium (technically a mineral, but often grouped with vitamins) helps regulate the nervous system. Some studies show it may reduce mild anxiety and improve sleep.

Omega-3 fatty acids (found in fish oil) aren’t vitamins, but they’re often recommended. They support brain cell function and may lower inflammation linked to mood disorders.

Important Notes

• Don’t self-treat: Supplements can interact with medications (e.g., high-dose B6 with certain antidepressants).
• Deficiency matters: Benefits are clearest when someone is actually low in a nutrient.
• Food first: A balanced diet rich in whole grains, vegetables, lean protein, and healthy fats is the best foundation.

Vitamin D, B6, B9 (folate), B12, and magnesium may support mental health—especially if you’re deficient. But they’re just one piece of the puzzle. For lasting relief from depression and anxiety, combine good nutrition with professional care, regular sleep, movement, and social connection.